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Sézary syndrome : ウィキペディア英語版
Sézary disease

Sézary disease (also known as Sézary's disease or Sézary('s) syndrome) () is a type of cutaneous lymphoma that was first described by Albert Sézary. The affected cells are T-cells that have pathological quantities of mucopolysaccharides. Sézary disease is sometimes considered a late stage of mycosis fungoides with lymphadenopathy. There are currently no known causes of Sézary disease.〔(【引用サイトリンク】 url=http://www.sezary.com/sezary-syndrome-causes.html )
==Signs and symptoms==

Sézary syndrome and mycosis fungoides are T-cell lymphomas whose primary manifestation is in the skin. The disease's origin is a peripheral CD4+ T-lymphocyte,〔 although rarer CD8+/CD4- cases have been observed.〔 Epidermotropism by neoplastic CD4+ lymphocytes with the formation of Pautrier's microabscesses is the hallmark sign of the disease.〔 The dominant symptoms of the disease are:
# Generalized erythroderma
# Lymphadenopathy
# Atypical T-cells ("Sézary cells") in the peripheral blood〔
# Hepatosplenomegaly

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Sézary disease」の詳細全文を読む



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